Centre for Genomic Regulation, Spain

Created in 2000, the Centre for Genomic Regulation (CRG) is a first-class multidisciplinary research centre with a total of 30 group leaders, of which half hold an ERC grant. Research is organized around four programmes: (i) Systems Biology, (ii) Bioinformatics and Genomics, (iii) Gene regulation, Stem Cells and Cancer and (iv) Cell and Developmental Biology. The CRG is one of only 10 life science research centres in Spain that has been awarded with a highly-competitive ‘Severo Ochoa’ grant of excellence (2017-2021). In addition, in 2013 the institute was awarded the HR Excellence logo by the European Commission to recognize the institute’s commitment to improve human resources policies for researchers.
Since 2013, the CRG is co-managing the European Genome- phenome Archive (EGA) in partnership with the EBI. The CRG is contributing with expertise in different areas, especially software development and database design. Since the 1st of July 2015 the Centro Nacional de Análisis Genómico (CNAG) is integrated into the CRG. CNAG is led by Dr. Ivo Gut and has a headcount of 66 staff. The centre is organized in two production-oriented groups for Sequencing and Bioinformatic Analysis that secure seamless operation, and three research groups focused on Bioinformatic Tools Development, Applied Genomics and Genome Biology. CNAG-CRG’s mission is to carry out projects in DNA sequence analysis for the improvement of quality of life in collaboration with the European and International Research Community.
The integrated CNAG-CRG infrastructure has one of the largest DNA sequencing capacities in Europe.
The CRG hosts a well-known International PhD Programme (currently training around 100 young researchers - almost 70% international) and a Postdoctoral Programme with highly talented young researchers, and provides mentoring and high- quality training courses, weekly seminars (Data Clubs, Journal Clubs, Lab Meetings, Programme Seminars and Group Leader seminars) and seminars with invited top speakers. The CRG also organizes high-level international courses, Courses@CRG, open to the scientific community.
The CNAG-CRG demonstrates proven experience in managing European projects: 71 from FP7, of which 9 were coordinated by our investigators. In H2020, 70 projects have already been awarded (including 10 ERCs, 9 coordinated projects and 1 COFUND INTREPiD). The CRG is one of the founders of the alliance of 13 top European research institutes in life sciences EU-LIFE to support and strengthen European research excellence.

The CRG includes the group of Prof. Marti-Renom, who has expertise in participating in several FP7 and H2020 projects. The team has also been one of the first ERC-Synergy awarded groups in 2013. In particular, the group has developed over the years 3D reconstruction methods for proteins, RNA and DNA molecules. This proposal is included in the latest efforts from the group to address the outstanding question of tissue reconstruction. The group has already secured a coordinated La Caixa grant to study tissue and tumour reconstruction from omics datasets in brain cancer in children.

Role in the project
CRG, through Prof. Marc A. Marti-Renom, will lead WP5, aimed at developing informatic and mathematical procedures to reconstruct and analyse the intestinal 3D multi-omic landscapes. CRG will also be in charge of data management, and will develop the 3D’omics visualisation platform. In total, CRG will be leading five tasks.